“Restriction of essential amino acids dictates the systemic response to dietary protein dilution” (2019)
https://www.biorxiv.org/content/10.1101/848143v1.full

Desulfuromonas are a genus of gram negative bacteria that reduce elemental sulfur. If we eat a high methionine based diet (high animal protein), we increase the number of desulfuromonas in our GI tract. The space available on the villi is limited and for optimal health, a bacteria in the GI tract need to be certain proportions. Lactobacillus numbers are decreased with high animal protein ingestion (high methionine) and they are not eliminated, they form spores. Each spore is takes up so much room that the space on the villi is no longer available and other needed bacteria are lost. The proportions of a healthy immune response are lost.

I could go into gram negative anaerobe issues from high methionine ingestion, but I try to keep these short. I sometimes get asked to write on various topics and do so on Facebook.

Hi Teresa, we do not sell methonine from our site. However, you may purchase it from Amazon or from iHerb.com

Hi, you can ask Joe inside of VIP: https://selfhacked.lpages.co/selfhackedvip/ or over at selfhacked.com/consult.

Oddly, Ive tried SAM-E before for a few days, didnt know 100% sure what to think of it for mood so stopped it, but certainly it wasnt giving me the overmethylation symptoms. Could L-methionine help or what should I take it? Im somewhat unmotivated and have flat affect.

(1) https://www.ncbi.nlm.nih.gov/books/NBK234922/table/ttt00008/?report=objectonly
(2) https://www.healthaliciousness.com/articles/high-methionine-foods.php

There are human studies done on methionine and humans and do show a correlation in a reduction of cancer, where methionine and proteins are lower. I will though add that all foods are not created equal. Food is a package deal. What you eat activates other nutrients or inhibits other nutrients as you mentioned the importance of b12.

Some of the studies you mentioned are done on animals. As you mentioned often animal studies don’t follow human biology and metabolism. So they are a base for a possible outcome in humans, but not a 1 for 1 replication.

I agree we are all different, but many scientific studies were done on humans of different genetic variances showed similar outcomes. So as some of us could smoke cigarettes and live to 100 most of us of various gene pools will be harmed by smoking. There is a lot of misinformation stating that just because genes are different than humans must follow a genetic diet. Similar to the blood type diet which was thrown out as bad science. Those with genetic mutations or variances that won’t follow the masses is far and few in between such as those with celiac disease. Trends carry when a lie is told enough times and then the mass begins to believe it.

In vegans, which I know many, they often come to the plant-based diet through issues with animals. They come from a lot of different backgrounds. All the vegans that I have met who follow a whole food plant based diet have shown a lowering in CRP, Cholesterol and have a lower incidence of cancer. There is not a vegan gene that causes vegans perform magic on their health. I myself genetically high cholesterol, with two uncles with stents and bypass. My mother Mediterranean diet had cholesterol of 315 and a clogged artery of 90 percent. My cholesterol 210 at age 11 and lowered my intake of fat and it is currently 144 and my CRP is 0.3. The CRP was also taken when I was consuming 3 to 4 glasses a day of kombucha which is high in fructose. I have cut out the amount since I realize that was not wise in general to consume that much. This was done with beans, whole grains, and greens primarily and eating an almost no oil diet, and low fat. I do get a good omega 6 to 3 ratio because my Omega 6 ratios are much lower because I am not eating a number of refined foods which are high in 6.

I have spent a decade plus studying the nutrition every day. Been so-called BIO-Hacking during this time. Some things bloggers write have validity but other time things are taken out of context or are not seeing the whole picture.

When people who biohack such as things like bulletproof diet and end up with heart disease they claim that they just were the only ones with bad genes. Genes are the loaded gun and diet and lifestyle pulls the trigger.

Here is an example of a study.
In humans,
vegan diets, which can be low in methionine, may prove to be a useful nutritional strategy in cancer
growth control. The development of methioninase which depletes circulating levels of methionine may
be another useful strategy in limiting cancer growth. The application of nutritional methionine restriction
and methioninase in combination with chemotherapeutic regimens is the current focus of clinical
studies.
Published by Elsevier Ltd. All rights reserved.

I think it is important to see that genes are not always your fate and to note that plant-based diets with low fat are the only diets to my knowledge that have shown to reverse atherosclerosis. This has been shown in people with all sorts of genetic backgrounds. Here is where that is shown in the Cleveland Clinic Study. http://dresselstyn.com/JFP_06307_Article1.pdf

But i have to say that in reading this article and similar content from cutting edge hacking and nutrition, i wonder what on earth are we doing. What happened to just eating a sensible, simple diet? Obsessing over every freaking nutrient, analyzing tests involving rats and flies, tripping on endless minutiae. We know too much. We’ve lost the plot. Have we learned nothing from the French?