Comments on: MDMA (Ecstasy) Effects, Dangers & PTSD Research

By: bennko

bennko — Mon, 12 Feb 2018 22:01:28 +0000

You’re over exaggerating the risks

By: Leanne

Leanne — Sun, 04 Feb 2018 01:38:50 +0000

My i cant believe what I have just read.. You should be so proud of yourself, I have bad days but what you have been through and pulled through is amazing. If you have found a coping mechanism thats fantastic. You may not need it forever. Dont let people judge, just be careful what you are taking x well done

By: Jani

Jani — Wed, 29 Nov 2017 20:05:32 +0000

Great comment, thank you! What is the guide you refer to sat the end of your post?

By: LIZEL

LIZEL — Fri, 11 Aug 2017 10:45:17 +0000

I only have posite things to say about this “drug”. I have been through severe traumas throughout my life including being raped, my house burning down with my wailing pets inside, a high-jacking at gunpoint, a boyfriend commiting suicide and a pshyciatric condition of crying the entire day since I was a little girl. I’ve been on various anti-depressants, clinics, herbal and whatnots which all had different effects but never cured all the symptoms. My chronic meds costs a huge amount every month. Since I have used a little amount of MDMA every few days I am a changed person. I can finally get out of bed, smile at people, do my job effieciently, have a normal relationship with someone and generally have a reason to live. My mind is sharper, I have no more outburst, as I have bipolar depression, I make the people around me happy. I am very clued up with my body and do not feel it ‘starting to actally work’ a certain time after I have taken it. I do not feel depressed a day or two afterwards and have absolutely no side-effects to report. There is no down afterwards, I am not dependant on it or addicted and I have a new appreciation for everything around me. I hate that it is illegal because it changed my life .around

By: John Stalks

John Stalks — Tue, 08 Aug 2017 18:03:50 +0000

Like everything else…be moderate in your usage. If you use it like a party drug, you will feel like you do after you party…hungover and like shit. I always take it alone. I do not take it often (2-3 times a year). I have never felt “bad” the next day. Ever. I get up and work out and continue my normal life. Drugs like shrooms, LCD, and MD ought to be treated with the utmost respect. Their are amazing “party” contexts in which to use these drugs, but respect their power. I cannot tell you how many people overdid it when they were 17-21 and cannot take these drugs 20 years later. These drugs get BETTER with age. The older you are, the more positive the experiences, because your life is generally richer anyway. No one should do any psychedelic drug until they have achieved a degree of self actualization, and they should be done rarely. There is nothing worse than someone who has abused the drug and cannot enjoy the benefits later in life. Just be smart and informed, and do it right.

By: Carenician

Carenician — Tue, 25 Jul 2017 07:35:48 +0000

Molly Long Term Effects
Craving
Feeling of paranoid
Hallucination
Agitation
Violent
High blood pressure
Increased respiratory rate
Palpitations
Headache

By: oh oh oh

oh oh oh — Sat, 08 Apr 2017 21:23:35 +0000

In reply to James. Thanks

By: Brett

Brett — Wed, 19 Oct 2016 15:27:00 +0000

Yeah, I second the experience of MDMA having severe serotonin depleting effects. Some people can tolerate it, but others seem to be neurochemically imbalanced in a terrible, debilitating way. I have observed some people suffering months of severe clinical depression following a single dose of pure product. Therefore, I do not recommend this particular drug – it has a well-known dark side.

By: Joseph M. Cohen

Joseph M. Cohen — Tue, 11 Oct 2016 04:49:46 +0000

In reply to James. Thanks!

By: James

James — Sun, 09 Oct 2016 21:45:29 +0000

As a once-heavy MDMA user, I just thought I’d throw in a few thoughts.

A common side effect reported by almost all heavy MDMA users is the “midweek blues”, a feeling of moderate to severe depression for a few days following MDMA use, caused by depleted levels of serotonin in the brain. Serotonin take several days to weeks to restore following depletion.

I took a medium dose of MDMA with my girlfriend once. The next evening, she was watching Shark Tank and just burst in to tears for no apparent reason – completely out of character for her.

I mention this because I’ve been able to consume extreme quantities of MDMA for up to 24-hour long binges. We’re talking 1 – 2 grams worth over an entire day. (Terrible, I know – I completely regret it and would never do it again knowing what I know now).

After those binges, I felt nothing but a bit tired the next day. No after-effects whatsoever in the following days. This seems to go completely against the crowd. I’ve never heard about anyone doing anything like that without days of comedown afterwards. Friends of mine could barely function at all following these binges, despite us all taking similar amounts and having similar tolerances.

I started researching the genetics responsible for MDMA metabolism. There’s some very interesting research available on Reddit which explains it far better than I could: https://www.reddit.com/r/DrugNerds/comments/13lp0b/mdma_neurotoxicity_part_1_metabolites/

It seems there are a few enzymes, CYP2D6, CYP450, and CYP3A4, primarily responsible for the metabolism of MDMA. Specifically, CYP3A4 metabolises MDMA in to MDA, which is more neurotoxic than MDMA alone (and also produces more hallucinogenic, psychedelic effects).

All this leads me on to the fact that grapefruit juice is a CYP3A4 inhibitor. This means, consuming a healthy amount of grapefruit juice prior to and during an MDMA session, prevents more of the MDMA metabolising in to MDA, thus leading to lower neurotoxicity risks.

A final point, if you want to take MDMA responsibility (a bit rich coming from me, I know), there is an excellent guide available at lists a wide variety of supplements (including grapefruit juice) to help reduce neurotoxicity.

Sorry for the ramble but just wanted to share these thoughts!