I recommend pulverizing it. A bullet or juicer. Consuming both the juice and pulp. You may want to mix in an apple or some other sweet fruit like blackberries, to lessen the bitter earthy taste.

He added: “What worries me is the appearance of the fruit in products of late given that it contains isoquinoline alkaloids that have been linked to the development of atypical Parkinson’s.”​

The recent interest in graviola appeared to be on the back of research suggesting it has anti-cancer properties, he said.

“I received inquiries on these ​[anti-cancer] claims… I was somewhat shocked given what I knew of its neurotoxicity when one caller mentioned that they were considering bringing it out as a juice.”​

Why is this not better known in the supplements trade?​

He added: “I spoke at a recent international symposium on the safety of natural products and mentioned soursop. Quite a number of scientists in the audience came from tropical/sub-tropical countries and recognized the fruit immediately when shown on a slide, but did not know about the associated neurotoxic compounds it contains. ​

“During lunch, one of the attendees did a PubMed search and confirmed my comments earlier that morning and asked why this was not better known.”​ ”

” Fruit and​ leaves represent potential risk​

Conerns have been raised about the leaf as well as the fruit, he added, citing papers by Champy et al (click here​ , here​ and here​). A phenomenologic study of parkinsonism by Caparros-Lefebvre in The Lancet​ also raises concerns about herbal teas, he added. Click here​.

NutraIngredients-USA has contacted several firms selling graviola supplements for comment including Raintree Nutrition, Swanson​ and Vitabase​ but has not had any feedback to date.

However, NOW Foods technical director Dr Michael Lelah said: “NOW Foods is aware of the potential safety concerns about graviola. We use a leaf extract which contains annonacin levels many times lower than the safe level. ​

“Additionally, no adverse events have been reported for our product. On the other hand, high concentrations of annonacin are found in the fruits or seeds, which are consumed by Caribbean populations.” ​ ”

“Epidemiological evidence​

The significance of these findings relates to the abnormally high rate of atypical parkinsonism found on islands such as Guam in the Northern Mariana islands, New Caledonia, western New Guinea, the Kii peninsula of Japan, and the French West Indian island of Guadeloupe in the Caribbean, where epidemiological evidence “suggests a close association of the disease with regular consumption of soursop fruit, infusions, and decoctions”, ​they observe.

“What is interesting is the virtual disappearance over the years of the disproportionate incidence of atypical parkinsonism previously reported in Guam and New Guinea. ​

“It has been suggested that the significant reduction in incidences may be due to changes in diet in New Guinea and in Guam, in particular owing to the adoption of Western diets and the abandonment of native foods, such as soursop.”​”
( https://www.nutraingredients-usa.com/Article/2012/05/10/Toxicology-expert-raises-alarm-over-potential-neurotoxins-in-graviola-soursop )

You may have missed this one, which has scary headlines we need to pay attention to if we are concerned about our brain health, IMO! Joe I think this one needs some kind of special alert or caution. You know how all of use are concerned about our brain performance!
( https://www.researchgate.net/publication/26744196_Natural_lipophilic_inhibitors_of_mitochondrial_complex_I_are_candidate_toxins_for_sporadic_tau_pathologies )