No dead ends. Some write ups are very one sided and have dead ends and leave me with more frustrating questions than open doors and pathways to better understanding/to learn more. Some writing I attempt to digest is geared for an audience of specialists in a field, and is too detailed and missing the introductory pieces of understanding for a lay person like me. This article seems to be quality writing with a purpose (and not fluff to just get something out there and get a pay check; like many writers on the internet seem to do too often.) But, alas! I am certainly no writer! I am a mom of three kids And husband who all have different, rare, genetic variances that cause rare manifestations or symptoms of their rare disease. I was looking to learn how to support optimal heart and liver function, in particular, and manage pain. If I had to use acetaminophen for my kids’ pain, which is said to greatly decrease glutathione levels in the individual using the NSAID, I was wondering how to support the body in replenishing levels and possible supplementation to restore glutathione levels. Thank u for this informative introductory read! Great start for me in understanding glutathione! I am grateful to have found this article!

Can Glutathione reverse Type 2 Diabetes that I will not have it again ? . Cheers

You lost me at Nrf2 pathway. Speak English, man! PS: if that’s you in the pic, you ain’t ageing well, bro. Not a good ad for your Nrf2 pathways. Maybe get a haircut and different glasses? Amirite, Joe? PS: publish my damnde comments. Cheers!

The key here is the presence of cofactors and attention to counter-productive SNPs such as CBS. B2 / B6 / Serine / Se / Vit C are needed to glutathione systhesis. If you activate Nrf2 pathway and you don’t have necessary cofactors present, you essentially will going to face increased oxidative stress.

So fix any issues with your transsulfuration pathway and then activate Nrf2 slowly. Nrf2 pathway actually causes small amount of oxidative stress to train cells for upcoming stress and cell reacts by upregulating CBS in order to increase glutathione. If you have CBS 699T, you want to ensure transurfuration pathway produce glutathione instead of ammonia and sulfites.

1. Reduce thiol foods
2. Take Moly for sulfite
3. Take Yasko’s CBS RNA + for ammonia
4. Follow this for 4-6 weeks
5. Take small amount of lean meat
6. Slowly introduce glutathione cofactors along with moly.
7. Induce nrf2 via curcumin or ginger
8. Take liposomal glutathione