By: Otto

Otto — Thu, 01 Jul 2021 20:42:50 +0000

Doesn’t galantamine causes mitochondrial damage?

By: Aaron

Aaron — Wed, 17 Feb 2021 03:46:38 +0000

A few months back I had testing done that confirmed my acetylcholinesterase and pseudocholinesterase levels are low, very likely since before my teen years when I started experiencing excessive sweating and post orgasm illness syndrome type symptoms. I was diagnosed with allergies and hyperhidrosis (excessive sweating), but anticholinergics/anhistamines have been a bandaid. I stopped taking them for years and became ill…mood/cognitive/affect/etc. due to a massive buildup of acetylcholine and organophosphates (show in urine testing). Also realized that I have something called post orgasm illness syndrome (symptoms were covered up by the anticholinergics/antihistamines). After orgasm, I get major dark circle/puffy eyes, am irritable, sweaty, anti-social, etc. There’s a clear connect with the defective AChE receptors. Additionally, urine testing showing high levels of organophosphates in my system. Let me know about the testing options as I had blood/plasma draws today and I can still add the antibody testing and remove the cholinesterase testing if need be. I don’t believe I’ve had high exposure to organophosphates lately. I’ve read that galantamine which is a reversible AChE inhibitor is supposed to be helpful in detoxing organophosphates and possibly “reversing” some of the “aged” receptors that were damaged, probably from anesthesia when I was a child. I don’t quite understand why an AChE inhibitor would be helpful if my AChE levels are already low. I have taken benedryl, chlorpheniramine, and hydroxizine in addition to oxybutynin. Recently, the nootropics piracetam, phenylpiracetam, bromantane and sulbuthiamine. Thoughts on how to prevent acetylcholine buildup (other than eating less choline)?

Comments on: Galantamine Uses, Side-Effects and More

By: Otto

By: Aaron