Comments on: Top 15 Natural Ways to Increase GABA

By: Arbab

Arbab — Fri, 07 May 2021 03:54:35 +0000

Hi.my son is 7 yrs old autistic ..he is hyperactive.sleep 9-10 hours per day..what herb should I give him for stress reliever and mind calmness focus attention

By: Adrienn

Adrienn — Thu, 24 Dec 2020 21:54:34 +0000

I found this a very informative and detailed article about this amino acid. At this point now I have one question that remained open (or more, but this is the first one), and as I am not a physician, I need further clarification on this: at the end of the article you mention that GABA supplements do not have any modifying effect on the brain GABA levels because they cannot cross the blood-brain barrier. It’s clear so far. But, is it a good news or bad news for supplement takers? In other words, does it mean that GABA supplements can be a safe way to increase GABA in the body because it does not alter the the brain’s function, or does it mean that GABA supplements do not have the desired and claimed effect at all?
I know it sounds a “laymen” question, but I am not a professional, just an enthusiast beginner researcher of the subject, mainly because I do researches about high sensitivity and about how people having HSP can cope with increased level of anxiety and menthal burnout (due to overstimulated nerve system).
Thank you very much in advance for your kind reply!

By: Mehdi

Mehdi — Mon, 16 Nov 2020 21:22:48 +0000

Hi
is the orange blossom has affect Gaba receptors?
thanks

By: Faiyaz

Faiyaz — Fri, 03 Jan 2020 23:00:00 +0000

Good article. Chinese Skullcap & Magnolia Bark are absolute staples in my GABA-agonist stack.

Regarding GABA’s ability to cross the BBB:
1. For those with a leaky BBB (such as myself), exogenous GABA will readily cross, even at low dosages. PharmaGABA (fermented using Lactobacillus Hilgardii) is my molecule of choice.
2. Crossing the BBB is not the only modality via which exogenous GABA can modulate signaling. Several gut bacteria produce and/or interact with GABA. As such, it is thought the enteric system via the gut-brain axis can potentiate GABA-ergic pathways post-supplementation.

By: cis

cis — Fri, 03 Jan 2020 20:20:42 +0000

But do these herbs and supplement have the butyrate-enhancing effect in the gut that GABA supposedly has?

By: Sara

Sara — Fri, 06 Sep 2019 19:38:51 +0000

This is fantastic.
I’ve tried many of these individually or combined, in tinctures in an effort to decrease motor tics and excessive blinking. After years of research and failed attempts, I learned this is an over activity of the brain and very much related to GABA depletion just the same as in Tourette’s syndrome.
It is difficult to find a concise list like this along with individual experiences such as yours. Thank you for this!

By: trueknowledge

trueknowledge — Sat, 15 Jun 2019 23:35:03 +0000

Thank you so much for this incredible article especially because it takes into account people with P450 polymorphisms (Kava interaction) which is so crucial to know. I’d never heard of magnolia being used for GABA fascinating and the article explains the mechanisms each remedy has on the receptors. Brilliant!

By: Conrad

Conrad — Sat, 10 Nov 2018 18:34:19 +0000

Gluatamate toxicity: Zinc, No way; take some Vit. B6 (Pyroxidine HCL) as pyridine-5’-phosphate, the active form has enzymes called PLP that are the one thing to get active GABA bound, causing Cl- depolarization, Impulses from neurological cells are “inhibited.” Binding sites are not remotely similar, ligand’s subunits are homogenous to the compound, the affinity has little to do with effect, intrinsic aptitude is the strength of GABA actually binds with a pore, which opioids do not negatively mod binding, carbamates are known to potentiate both. Ashwagandha hasn’t been even projected to modulate GABA, stress-reliever adaptogens and saying it’s like diazepam… no anticonvulsant/muscle relaxtion/sleepiness/cross-tolerance. Valproate/Valproic Acid is an Rx. Lactones from Kava… D1/2 agonist/CB1 agonist/acute onset hepatoxicity/mu & Delta opioid positive modulation… GABAb aka peripheral BBB GABA tolerance isn’t like a agonist to subunits it’s a2b, NMDA/NfKappa/BCL-2 and dopamine axonal spiny neurons, Alcohol is a cAMP and GABAr agonist like proforol & neuronsteriods. Magnolol & Honokiol with the 4-C CBD2 agonist. You need lipid and nitrogenous versions, theyre not hyrodophilic. Best one on here. GABAa PAM’s are not Kava everyday friendly liver and calm with good CBD:THC tinc. lemon balm and valerian root are good together. Taurine doesn’t bind to GABA… whoo, it’s a glutamate excitatory inhibitor. Helps gaba I guess. it’s essential taurine is the goods. Thanks for showing people how the compounds are personally what they wanna see/have. PLEASE research all these NIH.com/ PubChem are great. I’m an obsessive biochemistry phamacokinetic, if I know something about anything, all complex systems behavior internally and dynamically are wild and complex the kinetics of your body’s way to take things changes like food-likability for every other human.

By: Amelia

Amelia — Mon, 22 Oct 2018 23:31:35 +0000

Hey Joe! Can’t ZINC actually be beneficial for GABA by helping to remove Copper??? My Dr actaully recommended it to possibly help with gluatamate toxicity, especially people who have a copper overload tendency. Thoughts?

https://www.ncbi.nlm.nih.gov/m/pubmed/10864892/

By: Caroline Lam

Caroline Lam — Mon, 22 Oct 2018 22:19:35 +0000

In reply to Nancy Taylor. I fixed it for you :)

By: Nancy Taylor

Nancy Taylor — Fri, 12 Oct 2018 17:06:39 +0000

I just posted a comment (without checking it) and as it was going, I saw the exercise I referred to looked like it was 12 hours, as the / did not appear to make it a correct number of 1/2 hr

By: Nancy Taylor

Nancy Taylor — Fri, 12 Oct 2018 17:03:32 +0000

In reply to J Sandetson. I have been taking a GABA Calm in the evening and a 100mg Pharma GABA right b4 bed for about 3 months. This has great,y improved my sleep and mild anxiety. Just recently, I am feeling a tight pressure in the back of my head in the morning, which leaves me somewhat tired. My question is if there is a cumulative effect of GABA. When I stopped the Pharmacy Gaba, I was more alert in the morning, but after my regular 1/2 hr of exercise, I felt that pressure/tightness again.

By: Greg

Greg — Mon, 08 Oct 2018 00:02:06 +0000

In reply to Christine. If your son has Glutamate issues he should be be taking NAC and ALCAR. Ginkgo Biloba is also very useful.

By: Jacque

Jacque — Mon, 23 Jul 2018 10:23:38 +0000

I read that Pharma GABA can cross the blood brain barrier.
I think it was patented by a European research company but
it is available in several different brands in the US (found it on
Amazon and a few vitamin companies). I use the Natural Factors
brand of it (cheapest that I found). I have been using it for a couple of months and it really helps sleep issues and my blood pressure and anxiety have dropped considerably also. I personally would recommend that you try it.

By: Justin

Justin — Sat, 07 Apr 2018 22:01:32 +0000

GABA itself does cross the BBB, but it does it poorly. This is the main reason why people can get side effects if they take too much GABA at once.

By: George

George — Thu, 05 Apr 2018 22:50:18 +0000

How much Taurine did you take that is considered a hight dose?

By: Gibs

Gibs — Wed, 07 Feb 2018 10:45:07 +0000

Kava has norepinephrine transport inhibiting properties.

By: Mike Withers

Mike Withers — Wed, 22 Nov 2017 22:41:48 +0000

Apparently, “gates” in the blood barrier do indeed allow the oversize GABA molecule to penetrate. Can’t remember where I read it.

By: An-Marie

An-Marie — Thu, 14 Sep 2017 17:44:45 +0000

Which supplement is best to adress GABA B-receptor ?

By: Don Paladin

Don Paladin — Wed, 02 Aug 2017 01:54:19 +0000

You are welcome, Christine. Remember to remove the foods high in Glutamate (gluten in grains and casein in milk products). The key word in that article is BALANCE.

By: Christine

Christine — Wed, 02 Aug 2017 00:09:43 +0000

Thank you so much for suggesting the article about increasing GABA and balancing glutamate! My son has OCD and we just received some lab results. It turns out that his GABA level is extremely low and the glutamate level very high! This article is so helpful to us, I can’t thank you enough : )

By: Doug Gerard

Doug Gerard — Fri, 14 Jul 2017 21:47:31 +0000

If you take L-tryptophan or 5-htp along with a GABA supplement it is reported to allow the entry of the GABA into the brain more eaisily. Serotonin increases the permeability of the blood brain barrier ( AKA the “BBB”) which causes other substances to flow more freely into the CNS.

By: Don Paladin

Don Paladin — Tue, 11 Jul 2017 23:12:48 +0000

I have been reviewing several good GABA/Glutamate (GA) articles lately. If there is a gene error in GAD enzyme then GABA may not be effectively synthesized from GA.

Check this one on “How to Increase GABA and Balance Glutamate:” [holistichelp]

By: Deborah Gordon

Deborah Gordon — Mon, 12 Jun 2017 18:12:57 +0000

I’d love to hear your thoughts on gabapentin… seems to enhance deep sleep but maybe reduce BDNF…??