Comments on: Choline: Food sources, Benefits, Side Effects & Deficiency

By: MP

MP — Fri, 18 Dec 2020 08:57:47 +0000

about the conflicting information with impact on the heart… individuals who should manage or limit salt and water intake should avoid choline. some heart specialists don’t even know to advise their patients to avoid salt, and some people don’t know they have a cardiovascular problem or disposition. choline promotes salt retention which promotes water retention so you can see how this impacts heart or cardiovascular patients negatively. since so many people need to limit salt i cant believe there is such little understanding about this and no warning on B-Complex labels. for healthy people it might be good but with a type of hypertrophy ( Non Obstructive Hypertrophic Cardiomyopathy, enlarged heart ) choline promotes arrhythmia or palpitations, congestive heart failure, reduced energy, swelling or water on the lung (in breathing emergency try Atrovent puffer and diuretic). the heart or circulatory system cant handle all the extra water retention the choline in causing. in this case – urinate (or take a diuretic) but the choline is in conflict with the body’s internal balancing mechanism. so its not surprising to read choline may lead to worse outcomes in relation to cardiovascular. due to perspiration the problem with choline might be less obvious in the summer. i was able to confirm my suspicion about choline by reading Dr. Ronald Roth’s Research Library on Cellular Nutrition and Health Disorders: “Choline should be used with caution if there is a disposition for water retention (swollen hands or feet), since it boosts aldosterone activity, which in turn results in sodium retention”. for good reason there’s a few B-Complex producers that chose to leave out choline. i encourage the page author to add this contraindication above.

By: Lezyl

Lezyl — Mon, 23 Nov 2020 05:09:08 +0000

A study made on MX3 Capsule done in America and published in the Journal of Aging Resarch and Clinical Practice. It was concluded that MX3 Capsule helps improve mobility together with a good and healthy.
Thank you for sharing,
Keep sharing.

By: Kristopher James Smith

Kristopher James Smith — Wed, 24 Jun 2020 22:27:28 +0000

I eat fresh vegetables and fresh milk 3 times a day as to fight prostate cancer and also taking medicine by the doctors recommended. But I am worries about my friends recommendation that Food Supplement can help also to fight against diseases like prostate cancer. Please help me more on how to fight with it. Thank you and God bless!

By: Mark

Mark — Mon, 07 Oct 2019 03:22:34 +0000

Some studies show supplemental choline can ameliorate NAFLD but worsen glycemic control – at least in rodents:
https://diabetes.diabetesjournals.org/content/55/7/2015
https://www.ncbi.nlm.nih.gov/pubmed/23179947
http://www.jbc.org/content/288/2/837.full
https://www.hindawi.com/journals/jobe/2012/319172/

These studies contradict everything I’ve known about choline being lipolytic, inducing fat loss, etc. I wonder what the mechanism is. Perhaps taking choline on a LCHF diet worsens insulin sensitivity and glucose control as choline is a lipotropic and accelerates the release of FFAs into the bloodstream, thus inducing insulin resistance?

Those with PEMT/ MTHFD1 deficiencies certainly need supplemental choline to prevent or reverse NAFLD and all its dangers, but don’t want to become diabetic in the process.

Thoughts?

By: Pearl

Pearl — Fri, 04 May 2018 06:54:26 +0000

Wondering if there is an increased propensity for cardiovascular decease and prostate cancer how much of Alpha GPC is a safe amount to take for a female with propensity to cardiovascular decease and a male with propensity to prostate cancer. Correct amounts for each accordingly please. Thank you.

By: Piedad Rangel

Piedad Rangel — Tue, 10 Apr 2018 01:54:36 +0000

I have been constipated my entire life. Now realize that maybe taking choline could be a good alternative for me. I am vegetarian and do not consume too much eggs and cheese.
Do you suggest me to take it?
Thanks, great article.

By: Lang

Lang — Fri, 16 Feb 2018 04:06:19 +0000

I feel great on CDP-Choline with the exception that i can’t sleep. Any way around it? Brain doesn’t want to stop. Taking in the AM, but maybe it’s delayed and working evening and nights?

By: Doug

Doug — Sun, 14 Jan 2018 01:42:42 +0000

I read that Chris Masterjohn debunked the TMAO-Choline thing. Also, any truth to the idea that too much choline can tank cognition (biphasic)?

By: Marie

Marie — Mon, 23 Oct 2017 08:58:24 +0000

Hi Scott,
Curcumin is a major player in prevention or controlling prostate cancer ! Further, resveratrol, dark fruit, berries [polyphenols].
Marie

By: Attila

Attila — Thu, 21 Sep 2017 19:13:12 +0000

Maybe DMB found in olive oil can help to mitigate TMA then TMAO formation:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127123/

By: Issie

Issie — Tue, 02 May 2017 19:17:32 +0000

In reply to Issie. The other big help, that I left out is pregnenolone. Really gives a boost in energy and brain function. Issie

By: Issie

Issie — Tue, 02 May 2017 16:25:50 +0000

I’m finding that upping acetylcholine is being a great help to me. I’m rotating CDP choline and Huperzine A. Having recently learned I’m positive for Lupus Anticoagulant and thinning my blood with herbals and this combination – some very complex issues are greatly improving.

On Health rising, some of us are finding this to be beneficial.

Issie

By: David

David — Sun, 30 Apr 2017 11:33:39 +0000

Under: 6) Low Choline Levels May Increase Risk of Cancer you also say
“However, one study found that higher choline levels were associated with an increased risk of lethal prostate cancer [R].
Choline is highly concentrated in prostate cancer cells, and blood concentrations of choline have been associated with an increased risk of prostate cancer [R].”
So I’d say this puts quite a damper on your Go Choline pro egg industry ‘scientific’ rant.

By: Nolan

Nolan — Fri, 27 Jan 2017 21:20:13 +0000

Excellent writeup.

CDP-Choline was shown to increase SIRT1 in neurons and confer some protection from the deleterious effect of stroke:

“Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke.”
https://www.ncbi.nlm.nih.gov/pubmed/23600725

By: Alice Aman

Alice Aman — Mon, 12 Dec 2016 05:35:23 +0000

What about help for a fatty liver (NAFLD)? Which version of Choline is best for that? Or is there another supplement one should take (besides having a healthy diet).?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601486/
http://lpi.oregonstate.edu/mic/other-nutrients/choline

By: Natcha M

Natcha M — Sat, 03 Dec 2016 00:15:30 +0000

In reply to Scott Murray. Supplements? Also you can get it in egg yolk, soy, sunflower, and liver. Not that soy is healthy. ~Team SelfHacked

By: Scott Murray

Scott Murray — Tue, 29 Nov 2016 12:45:48 +0000

I do not eat red meat and eat chicken and turkey occasionally. I have a history of prostate cancer in my family . I want to make sure I get enough choline for brain and body health but am concerned about the cancer risk.
How much is safe to take and do you have any suggestions??
Thanks !

By: Joseph M. Cohen

Joseph M. Cohen — Tue, 14 Jun 2016 20:34:32 +0000

In reply to Paul.

Thanks, it’s a good thing I also take resveratrol
http://mbio.asm.org/content/7/2/e02210-15.abstract

By: Paul

Paul — Tue, 14 Jun 2016 05:33:14 +0000

Seems that choline ingestion can lead to heart disease and prostate cancer by known mechanisms: http://www.ncbi.nlm.nih.gov/pubmed/22952174
http://www.ncbi.nlm.nih.gov/pubmed/19423531
http://www.nejm.org/doi/full/10.1056/NEJMoa1109400?query=featured_home&
http://www.ncbi.nlm.nih.gov/pubmed/21475195

By: anna burns

anna burns — Mon, 13 Jun 2016 12:40:24 +0000

What about getting choline from lecithin? It’s in a whole food form and seems would be more bioavailable. I really like sunflower seed lecithin, not so hot about soy lecithin. Just wondering your opinion. Thanks