Comments on: What is Cardarine (GW501516)? + Side Effects, Dangers

By: Ambrox

Ambrox — Tue, 28 Sep 2021 21:25:52 +0000

Tobacco also is proven to cause cancer.

By: Dr. Stuart McKewon

Dr. Stuart McKewon — Sat, 27 Mar 2021 19:23:55 +0000

Lazy article, as stated in the comments, doses linked to genotoxic activity were absurdly high. I tell my patients to do proper diligence about cardarine, it is a game changer for some.

By: Alan

Alan — Fri, 19 Feb 2021 21:17:24 +0000

In the studies I read the does they were giving the tiny mice were multiple times higher than the highest does a human would take. At these levels I am not surprised it was carcinogenic.

I have used it maybe once a month. It does work. My wife has respiratory issues and takes it when she is struggling and it helps.

I wonder what the risk levels are with infrequent use?

By: Shawn Ward

Shawn Ward — Wed, 13 Jan 2021 08:08:55 +0000

I just started taking cardarine. I’ve been on it for about a week. Taking 20 mg a day I have noticed a drastic difference in nitric oxide vasodilation, my arms have substantially got bigger so is my chest and legs, I’m also taking anti cancerous mushroom extracts such as reishi cordyceps and lion’s mane I’m also taking ultra thistle as a liver protectant. This is week one, I’ll be back when the six weeks is up and let you know the results I’m also keeping extreme awareness have any negative side effects, other than the acne so far I’ve seen none that remains to be seen though, let’s just see where this takes me. Sorry for the typos I’m driving

By: Sean

Sean — Wed, 05 Aug 2020 11:54:52 +0000

The study showing cancer causing was alongside a carnicogen was it not?

By: Doris

Doris — Wed, 20 May 2020 23:29:50 +0000

I’m surprised to see the eye issues on here. I suffer from multiple inflammatory issues including uveitis. I was on Humira and Methotrexate for two years and saw no results. It was so bad that blood was leaking into the inside of my eye, the only thing that helped was extremely high doses of prednisone and the side effects were horrible. I started this because I read that it can help inflammation and within one week I no longer see blood streaming through my vision, my joints no longer hurt as bad as they have for years, and even the pain of what was labeled as fibromyalgia is almost non-existent.

By: Doris

Doris — Wed, 20 May 2020 23:02:17 +0000

In reply to BEFIT. Have you tried to use SR9009? I have just started so I can't speak from experience but I work where it's sold so I've looked into it and it's supposed to be good for getting rid of that stubborn bit that hangs on or for breaking a plateau.

By: Jerrod

Jerrod — Mon, 25 Nov 2019 11:42:53 +0000

Follow up determined that it was dosed at levels that we wouldn’t dose anything else, approximately 45mg per kg. If you took aspirin at that dosage you would die flat out. I can confirm that other studies confirmed that it would worsen existing liver diseases. Forums that follow SARMs and related compounds, dose at 12 and 24 mg period. Small studies done by these sites did confirm that they had they listed benefits.

By: Rick

Rick — Sun, 27 Oct 2019 23:09:28 +0000

Good info but the cancer risk from gw1516 was found only in mice and the dosage was incredibly high in which no sane person would take. The mice were also injected with drug for 2 years. If you could, post the research papers from the animal test so we all could be fully informed.

By: Chris

Chris — Wed, 05 Jun 2019 15:25:46 +0000

These types of items (sarms included) will harm liver, kidneys and cardiovascular systems. Dont let people fool you. get blood work and see for yourself.

By: BEFIT

BEFIT — Tue, 21 May 2019 20:29:59 +0000

For those who have tried Cardarine (specifically females), when you are on your off cycle, do you find your weight comes back? I am not a die hard weight lifter and don’t plan to use Cardarine long term, but I do go to the gym regularly. I just want assistance loosing that extra stubborn fat and the extra energy that some talk about. Also, how severe is the acne side affect of it?

By: Todd Staten

Todd Staten — Wed, 01 May 2019 20:52:30 +0000

Big Pharma likes to majorly downplay the millions of deaths every year from taking “safe” drugs! The POSSIBILITY of cancer with long term use (cycle people) is much better than the myriad of side effect that can come from ANY other “safe” drug!

By: Jeffrey Florentino

Jeffrey Florentino — Tue, 30 Apr 2019 22:43:50 +0000

In reply to Lou steakley.

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By: Lou steakley

Lou steakley — Mon, 22 Apr 2019 00:17:37 +0000

Would you please tell me the best way to take cardarine in the liquid form? And is it supposed to burn when swallowing?

By: DDearborn

DDearborn — Sun, 11 Nov 2018 19:22:41 +0000

In reply to australopithicus. Hmmm Given your comments fail address either the facts that author provided or the conclusions he introduced, let alone any sort of credible rebuttal in that regard, I question your true motives for writing them. Ad hominem attacks such as yours offer readers (like me) little assurance that you anything other than a condescending big Pharma shrill.

By: Marcus

Marcus — Sun, 11 Nov 2018 17:08:14 +0000

It seems there are side effects that are not mentioned one would be for me was acne on the chest back and arms. I took the recommended dosage 20 mg a day for about 6 weeks. I have never had acne on my arms or back for chest now I have a problem I hope we’ll go away. Has anyone had this effect before?

By: Josh

Josh — Sat, 13 Oct 2018 04:16:17 +0000

Cardarine works! I did a 12 cycle with that and LGD-4033 and Ostarine and that stack was phenomenal! I had great strength gains and muscle retention. I recommend people give cardarine a try. FYI I never take more then 20mg a day. the half life of it is like 18 hours so I don’t think it really matters when you take it. I just take it first thing when getting up. Also, CYCLE! Don’t take it for 2 years straight, that’s when the rats came down with cancer. I personally don’t think its that bad if you cycle it. Just be smart and use in moderation and you’ll be fine as there are a of logs out there of people and their cycles.

By: Agostoso pika das galáxias

Agostoso pika das galáxias — Thu, 02 Aug 2018 21:38:14 +0000

excellent article, and comments helped a lot to clear my doubts !!

By: Tim

Tim — Sat, 14 Jul 2018 11:53:45 +0000

Hi
I’ve struggled with major distension and bloating for 5 years and I have noticed that Within one day of taking this my bloating disappeared. I have tried this on 6 different occasions as a test to see if it was the GW and it seems to be so.. what I want to know is 1: if others have noticed this ? 2: this isn’t fat loss but distension and bloating actually disappearing. So what mechanism is causing the bloating to go away that quick when nothing else has worked for 5 years and I mean nothing .
Any insight would be appreciated

By: Dino

Dino — Mon, 21 May 2018 20:08:56 +0000

I took 3 x 7.5mg on Thursday before running and been ill since friday lunch time, I’ve had servere headaches and the backs of my eyes are hurting and my vision has been impaired. I am currently in hospital. I wish i read all your comments before i bought them i hope my eye sight is not permanently damaged

By: Shea

Shea — Mon, 09 Apr 2018 20:02:34 +0000

In reply to Martin. Thanks for you detailed and informative response, Martin! :)

By: Baydoll

Baydoll — Mon, 02 Apr 2018 23:40:45 +0000

How are you taking it?

By: Baydoll

Baydoll — Mon, 02 Apr 2018 23:37:28 +0000

I felt great on day one..the workout was amazing. I had so much energy and every workout after .I couldn’t notice on myself until ppl started asking me what I was doing to lose weight.thats when I started looking and trying on old clothes I couldnt fit before I started. I’m not a body builder but I gained muscle and did burn alot of fat.i started in February and it’s April and I’m happy still have more to do. This is my off cycle now I’mma start back in May for my final cycle.i have before pictures I want to post in July so I can show before and after…just to show a 6mnth progress…but once again I didn’t stack it with anything else not even a energy drink..just water…well I hope this helps you.

By: Martin

Martin — Mon, 02 Apr 2018 03:38:25 +0000

Hello, the eye side effects seems very concerning, what is happening seems similar to age related macular degeneration (AMD). Not point in looking good if you get blind.

I found these studies that perhaps could help as they help with AMD, as the problem there also is neovascularization growth of new blood vessels.

Just for your information to perhaps discuss with your doctors,

Atorvastatin (perhaps easier, cheaper and better than getting injection into the eyes)
(Statins also lowers one factor involved in AMD, that is called VEGF (vascular endothelial growth factor).
https://eye.hms.harvard.edu/news/patients-high-risk-macular-degeneration-show-improvement-high-dose-statin-treatment
https://www.reviewofophthalmology.com/article/amd-and-statins-is-there-an-association

And a blood pressure medicine, telmerisartan, as it seems to reduce many of the mediators involved in AMD as well (including VEGF and other factors)

Hypertension is a potential link between cardiovascular pathologies and eye diseases. A large amount of information has demonstrated the presence of a RAS (refers to how blod pressure is regulated) in the retina which is greatly spread in the vasculature. To date, findings from epidemiological studies indicate an association between AMD and hypertension. Moreover, studies in vitro and in vivo show that Ang II contributes to sub-RPE deposit formation and CNV development and that these events can be improved by Ang II receptor blockers (ARBs). However, the utility of ARBs for the treatment of eye AMD is still to be determined. In terms of DR (diabetic retinopathy), there is documented evidence showing a clear contribution of Ang II to the development of this disease. Therefore, the use of ARBs (including telmerisartan) can confer retinoprotection and arrest the progression of DR.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176806/

Study with atorvastatin with aspirin
http://www.blindness.org/treatments/cholesterol-lowering-statin-drugs-and-aspirin-show-protection-against-wet-amd
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939755/ (just aspirin for ARMD)

A animal disease model that shows telmerisartan and aspirin could work for a similar condtion that happends in the kidneys
https://www.researchgate.net/publication/41909567_Combination_of_aspirin_with_telmisartan_suppresses_the_augmented_TGFbsmad_signaling_during_the_development_of_streptozotocin-induced_type_I_diabetic_nephropathy